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SERVICE D'ENDOCRINOLOGIE, DIABETE ET MALADIES METABOLIQUESCHU Timone / 264 rue Saint-Pierre / 13385 Marseille 05
Téléphone : 04-91-38-65-97
Fax : 04-91-38-45-42
Courriel : thierry.brue@ap-hm.fr
Equipes Acueil des Masters Contrats Liste des Personnels Publications des 2 dernières années Thèses
| Effectifs |
Enseignants - Chercheurs et Ingénieurs Universitaires : 3
Médecins hospitaliers : 2
Chercheurs et Ingénieurs (INSERM, CNRS, autres) : 1
Personnel Administratif et Technique Universitaire : 0
Personnel Administratif et Technique (INSERM, CNRS, autres) : 0
Internes : 2
Etudiants (3ème cycle,Post-Doc, Boursiers...) : 3
| Eaquipes de recherche 'mise à jour du 22/02/12' |
- Physiopathologie des tumeurs hypophysaires - I. Morange, F. Castinetti - (Responsable : Thierry BRUE)
- Hypopituitarisme congénital et facteurs de transcription hypophysaires - (Responsable : Thierry BRUE)
- Registres nationaux de l'acromégalie et de la maladie de Cushing - T. Brue, M. Fathallah - (Responsable : Frédérique ALBAREL)
- Effets endocriniens des traumatismes craniens - I. Morange, N. Morlet-Barla - (Responsable : Thierry BRUE)
- Maladies de Cushing - F. Castinetti - (Responsable : Thierry BRUE)
- Recherche clinico-biologique en pathologies endocriniennes (thyroïde, parathyroïde, surrénales) - (Responsable : Bernard CONTE-DEVOLX )
- Tumeurs endocrines familiales - (Responsable : Bernard CONTE-DEVOLX )
| - | "MAGNET : Signal Transduction Mediated by Somatostatin Receptor Pan-agonist Pasireotide in Association with mTOR inhibitor Everolimus in Neuroendocrine Tumors (NET)" - BRUE T. - 2010-2012 - NOVARTIS PHARMA |
| - | « PERSPICACITY, PEgvisomant: Role on Secretion, Proliferation & IntraCellulAr pathways in GH Cells in pITuitarY » - BRUE T./BARLIER A. - 2010-2012 - PFIZER INTERNATIONAL |
| - | MDPHD : Nouveaux déterminants moléculaires des déficits hypophysaires - T. BRUE - 2008 - ANR 08 GENOPAT 026 - BRUE T. - 2008-2012 - ANR |
| ALBAREL Frédérique - PH | 04-91-38-65-97 |
| BRUE Thierry - PU-PH | 04-91-38-55-05 |
| CASTINETTI Frédéric - CCA/Doctorant | 04-91-38-65-97 |
| CONTE-DEVOLX Bernard - PU-PH | 04-91-38-65-97 |
| FATHALLAH/SAHNOUN Mona - Ingénieur de Recherche | 04-91-38-65-97 |
| MORANGE-RAMOS Isabelle - PH | 04-91-38-65-97 |
| Publications des 2 dernières années |
| - | Brue T, Castinetti F, Lundgren F, Koltowska-Häggström M, Petrossians P; ACROSTUDY investigators. Which patients with acromegaly are treated with pegvisomant? An overview of methodology and baseline data in ACROSTUDY. Eur J Endocrinol. 2009 Nov;161 Suppl 1:S11-7. |
| - | Brue T. ACROSTUDY: Status Update on 469 Patients. Horm Res. 2009 Jan;71 Suppl 1:34-8. Brue T, Wémeau JL. [Pituitary adenomas: an earlier diagnosis]. Presse Med. 2009 Jan;38(1):74-5. |
| - | Castinetti F, Morange I, Dubois N, Albarel F, Conte-Devolx B, Dufour H, Brue T. Does first-line surgery still have its place in the treatment of acromegaly? Ann Endocrinol (Paris). 2009 Apr;70(2):107-12. |
| - | Castinetti F, Martinie M, Morange I, Dufour H, Sturm N, Passagia JG, Conte-Devolx B, Chabre O, Brue T. A combined dexamethasone desmopressin test as an early marker of postsurgical recurrence in Cushing's disease. J Clin Endocrinol Metab. 2009 Jun;94(6):1897-903. |
| - | Castinetti F, Fassnacht M, Johanssen S, Terzolo M, Bouchard P, Chanson P, Do Cao C, Morange I, Picó A, Ouzounian S, Young J, Hahner S, Brue T, Allolio B, Conte-Devolx B. Merits and pitfalls of mifepristone in Cushing's syndrome. Eur J Endocrinol. 2009 Jun;160(6):1003-10. |
| - | Castinetti F, Brue T. [Radiotherapy and radiosurgery of pituitary adenomas]. Presse Med. 2009 Jan;38(1):133-9. |
| - | Castinetti F, Morange I, Dufour H, Regis J, Brue T. Radiotherapy and radiosurgery in acromegaly. Pituitary. 2009;12(1):3-10. |
| - | Castinetti F, Nagai M, Morange I, Dufour H, Caron P, Chanson P, Cortet-Rudelli C, Kuhn JM, Conte-Devolx B, Regis J, Brue T. Long-term results of stereotactic radiosurgery in secretory pituitary adenomas. J Clin Endocrinol Metab. 2009 Sep;94(9):3400-7. |
| - | Castinetti F, Saveanu A, Morange I, Brue T. Lanreotide for the treatment of acromegaly. Adv Ther. 2009 Jun;26(6):600-12. |
| - | Chanson P, Bertherat J, Beckers A, Bihan H, Brue T, Caron P, Chabre O, Cogne M, Cortet-Rudelli C, Delemer B, Dufour H, Gaillard R, Gueydan M, Morange I, Souberbielle JC, Tabarin A; Club Français De L'hypophyse (French Pituitary Club); Société Française Dendocrinologie (French Endocrinology Society). French consensus on the management of acromegaly. Ann Endocrinol (Paris). 2009 Apr;70(2):92-106. |
| - | Conway GS, Szarras-Czapnik M, Racz K, Keller A, Chanson P, Tauber M, Zacharin M; 1369 GHD to GHDA Transition Study Group. Treatment for 24 months with recombinant human GH has a beneficial effect on bone mineral density in young adults with childhood-onset GH deficiency. Eur J Endocrinol. 2009 Jun;160(6):899-907. |
| - | Crand A, Borson-Chazot F, Brue T. [Recent data in adrenocortical tumorigenesis]. Ann Endocrinol (Paris). 2009 Sep;70 Suppl 1:S20-5. |
| - | Dupuy O, Petrossians P, Brue T, Morange I, Bordier L, Mayaudon H, Bauduceau B; le groupe des investigateurs du registre français de l'acromégalie. [Acromegaly in the elderly]. Ann Endocrinol (Paris). 2009 Sep;70(4):225-9. |
| - | Jaffrain-Rea ML, Angelini M, Gargano D, Tichomirowa MA, Daly AF, Vanbellinghen JF, D'Innocenzo E, Barlier A, Giangaspero F, Esposito V, Ventura L, Arcella A, Theodoropoulou M, Naves LA, Fajardo C, Zacharieva S, Rohmer V, Brue T, Gulino A, Cantore G, Alesse E, Beckers A. Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications. Endocr Relat Cancer. 2009 Sep;16(3):1029-43. |
| - | Melmed S, Colao A, Barkan A, Molitch M, Grossman AB, Kleinberg D, Clemmons D, Chanson P, Laws E, Schlechte J, Vance ML, Ho K, Giustina A; Acromegaly Consensus Group. Guidelines for acromegaly management: an update. J Clin Endocrinol Metab. 2009 May;94(5):1509-17. |
| - | Taïeb D, Sebag F, Barlier A, Tessonnier L, Palazzo FF, Morange I, Niccoli-Sire P, Fakhry N, De Micco C, Cammilleri S, Enjalbert A, Henry JF, Mundler O. 18F-FDG avidity of pheochromocytomas and paragangliomas: a new molecular imaging signature? J Nucl Med. 2009 May;50(5):711-7. |
| - | Touraine P, D'Souza GA, Kourides I, Abs R, Barclay P, Xie R, Pico A, Torres-Vela E, Ekman B; GH Lipoatrophy Study Group. Lipoatrophy in GH deficient patients treated with a long-acting pegylated GH. Eur J Endocrinol. 2009 Oct;161(4):533-40. |
| - | Caron P, Broussaud S, Bertherat J, Borson-Chazot F, Brue T, Cortet-Rudelli C, Chanson P. Acromegaly and pregnancy: a retrospective multicenter study of 59 pregnancies in 46 women. J Clin Endocrinol Metab. 2010 Oct;95(10):4680-7. |
| - | Carvalho LR, Brinkmeier ML, Castinetti F, Ellsworth BS, Camper SA. Corepressors TLE1 and TLE3 interact with HESX1 and PROP1. Mol Endocrinol. 2010 Apr;24(4):754-65. |
| - | Castinetti F, Brue T. Gamma Knife radiosurgery in pituitary adenomas: Why, who, and how to treat? Discov Med. 2010 Aug;10(51):107-11. |
| - | Castinetti F, Conte-Devolx B, Brue T. Medical treatment of Cushing's syndrome: glucocorticoid receptor antagonists and mifepristone. Neuroendocrinology. 2010;92 Suppl 1:125-30. |
| - | Castinetti F, Régis J, Dufour H, Brue T. Role of stereotactic radiosurgery in the management of pituitary adenomas. Nat Rev Endocrinol. 2010 Apr;6(4):214-23. |
| - | Chanson P, Cailleux-Bounacer A, Kuhn JM, Weryha G, Chabre O, Borson-Chazot F, Dubois S, Vincent-Dejean C, Brue T, Fedou C, Bresson JL, Demolis P, Souberbielle JC. Comparative validation of the growth hormone-releasing hormone and arginine test for the diagnosis of adult growth hormone deficiency using a growth hormone assay conforming to recent international recommendations. J Clin Endocrinol Metab. 2010 Aug;95(8):3684-92. |
| - | Conte-Devolx B, Morlet-Barla N, Roux F, Sebag F, Henry JF, Niccoli P. Could primary hyperparathyroidism-related hypercalcemia induce hypercalcitoninemia? Horm Res Paediatr. 2010;73(5):372-5. |
| - | Conte-Devolx B, Niccoli P; Groupe d'étude des Tumeurs Endocrines. [Clinical characteristics of multiple endocrine neoplasia]. Bull Acad Natl Med. 2010 Jan;194(1):69-78; discussion 78-9. |
| - | Daly AF, Tichomirowa MA, Petrossians P, Heliövaara E, Jaffrain-Rea ML, Barlier A, Naves LA, Ebeling T, Karhu A, Raappana A, Cazabat L, De Menis E, Montañana CF, Raverot G, Weil RJ, Sane T, Maiter D, Neggers S, Yaneva M, Tabarin A, Verrua E, Eloranta E, Murat A, Vierimaa O, Salmela PI, Emy P, Toledo RA, Sabaté MI, Villa C, Popelier M, Salvatori R, Jennings J, Longás AF, Labarta Aizpún JI, Georgitsi M, Paschke R, Ronchi C, Valimaki M, Saloranta C, De Herder W, Cozzi R, Guitelman M, Magri F, Lagonigro MS, Halaby G, Corman V, Hagelstein MT, Vanbellinghen JF, Barra GB, Gimenez-Roqueplo AP, Cameron FJ, Borson-Chazot F, Holdaway I, Toledo SP, Stalla GK, Spada A, Zacharieva S, Bertherat J, Brue T, Bours V, Chanson P, Aaltonen LA, Beckers A. Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study. J Clin Endocrinol Metab. 2010 Nov;95(11):E373-83. |
| - | Davis SW, Castinetti F, Carvalho LR, Ellsworth BS, Potok MA, Lyons RH, Brinkmeier ML, Raetzman LT, Carninci P, Mortensen AH, Hayashizaki Y, Arnhold IJ, Mendonça BB, Brue T, Camper SA. Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol. 2010 Jul 8;323(1):4-19. |
| - | Leyer C, Castinetti F, Morange I, Gueydan M, Oliver C, Conte-Devolx B, Dufour H, Brue T. A conservative management is preferable in milder forms of pituitary tumor apoplexy. J Endocrinol Invest. 2010 Aug 31. |
| - | Luca F, Goichot B, Brue T. [Non thyroidal illnesses (NTIS)]. Ann Endocrinol (Paris). 2010 Sep;71 Suppl 1:S13-24. |
| - | Nyström HF, Saveanu A, Barbosa EJ, Barlier A, Enjalbert A, Glad C, Palming J, Johannsson G, Brue T. Detection of genetic hypopituitarism in an adult population of idiopathic pituitary insufficiency patients with growth hormone deficiency. Pituitary. 2010 Dec 5. |
| - | Petersenn S, Schopohl J, Barkan A, Mohideen P, Colao A, Abs R, Buchelt A, Ho YY, Hu K, Farrall AJ, Melmed S, Biller BM; Pasireotide Acromegaly Study Group. Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: a randomized, multicenter, phase II trial. J Clin Endocrinol Metab. 2010 Jun;95(6):2781-9. |
| - | Philibert P, Audran F, Pienkowski C, Morange I, Kohler B, Flori E, Heinrich C, Dacou-Voutetakis C, Joseph MG, Guedj AM, Journel H, Hecart-Bruna AC, Khotchali I, Ten S, Bouchard P, Paris F, Sultan C. Complete androgen insensitivity syndrome is frequently due to premature stop codons in exon 1 of the androgen receptor gene: an international collaborative report of 13 new mutations. Fertil Steril. 2010 Jul;94(2):472-6. |
| - | Quentien MH, Vieira V, Menasche M, Dufier JL, Herman JP, Enjalbert A, Abitbol M, Brue T. Truncation of PITX2 differentially affects its activity on physiological targets. J Mol Endocrinol. 2010 Dec 21;46(1):9-19. |
| - | Raverot G, Wierinckx A, Dantony E, Auger C, Chapas G, Villeneuve L, Brue T, Figarella-Branger D, Roy P, Jouanneau E, Jan M, Lachuer J, Trouillas J; HYPOPRONOS. Prognostic factors in prolactin pituitary tumors: clinical, histological, and molecular data from a series of 94 patients with a long postoperative follow-up. J Clin Endocrinol Metab. 2010 Apr;95(4):1708-16. |
| - | Raverot G, Sturm N, de Fraipont F, Muller M, Salenave S, Caron P, Chabre O, Chanson P, Cortet-Rudelli C, Assaker R, Dufour H, Gaillard S, François P, Jouanneau E, Passagia JG, Bernier M, Cornélius A, Figarella-Branger D, Trouillas J, Borson-Chazot F, Brue T. Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: a French multicenter experience. J Clin Endocrinol Metab. 2010 Oct;95(10):4592-9. |
| - | Regis J, Castinetti F. Radiosurgery: a useful first-line treatment of prolactinomas? World Neurosurg. 2010 Jul;74(1):103-4. |
| - | Roussel-Gervais A, Bilodeau S, Vallette S, Berthelet F, Lacroix A, Figarella-Branger D, Brue T, Drouin J. Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis. Mol Endocrinol. 2010 Sep;24(9):1835-45. |
| - | Sarfati J, Guiochon-Mantel A, Rondard P, Arnulf I, Garcia-Piñero A, Wolczynski S, Brailly-Tabard S, Bidet M, Ramos-Arroyo M, Mathieu M, Lienhardt-Roussie A, Morgan G, Turki Z, Bremont C, Lespinasse J, Du Boullay H, Chabbert-Buffet N, Jacquemont S, Reach G, De Talence N, Tonella P, Conrad B, Despert F, Delobel B, Brue T, Bouvattier C, Cabrol S, Pugeat M, Murat A, Bouchard P, Hardelin JP, Dodé C, Young J. A comparative phenotypic study of kallmann syndrome patients carrying monoallelic and biallelic mutations in the prokineticin 2 or prokineticin receptor 2 genes. J Clin Endocrinol Metab. 2010 Feb;95(2):659-69. |
| - | Simon N, Castinetti F, Ouliac F, Lesavre N, Brue T, Oliver C. Pharmacokinetic evidence for suboptimal treatment of adrenal insufficiency with currently available hydrocortisone tablets. Clin Pharmacokinet. 2010 Jul 1;49(7):455-63. |
| - | Skandarajah A, Barlier A, Morlet-Barlat N, Sebag F, Enjalbert A, Conte-Devolx B, Henry JF. Should routine analysis of the MEN1 gene be performed in all patients with primary hyperparathyroidism under 40 years of age? World J Surg. 2010 Jun;34(6):1294-8. |
| - | Taïeb D, Sebag F, Farman-Ara B, Portal T, Baumstarck-Barrau K, Fortanier C, Bourrelly M, Mancini J, De Micco C, Auquier P, Conte-Devolx B, Henry JF, Mundler O. Iodine biokinetics and radioiodine exposure after recombinant human thyrotropin-assisted remnant ablation in comparison with thyroid hormone withdrawal. J Clin Endocrinol Metab. 2010 Jul;95(7):3283-90. |
| - | Tessonnier L, Sebag F, Ghander C, De Micco C, Reynaud R, Palazzo FF, Conte-Devolx B, Henry JF, Mundler O, Taïeb D. Limited value of 18F-F-DOPA PET to localize pancreatic insulin-secreting tumors in adults with hyperinsulinemic hypoglycemia. J Clin Endocrinol Metab. 2010 Jan;95(1):303-7. |
© Faculté de Médecine de Marseill l Mentions légales l Mise à jour du 22 février 2012