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LABORATOIRE DE NEUROBIOLOGIE DES INTERACTIONS CELLULAIRES ET NEUROPHYSIOPATHOLOGIE (N.I.C.N.)UFR de Médecine - Site Nord - UMR 6184 / 51 Bd Pierre Dramard / 13344 Marseille 15
Téléphone : 04-91-69-87-29 / 0491698964
Fax : 04-91-25-89-70
Courriel : michel.khrestchatisky@univmed.fr
Equipes Acueil des Masters Contrats Liste des Personnels Publications des 2 dernières années Thèses
| Effectifs |
Enseignants - Chercheurs et Ingénieurs Universitaires : 3
Médecins hospitaliers :
Chercheurs et Ingénieurs (INSERM, CNRS, autres) : 20
Personnel Administratif et Technique Universitaire : 2
Personnel Administratif et Technique (INSERM, CNRS, autres) : 7
Internes :
Etudiants (3ème cycle,Post-Doc, Boursiers...) : 8
| Equipes de recherche |
- E1-Dégénérescence et plasticité neurales - (Responsable : Santiago RIVERA)
- E2-Plasticité olfactive et réparation du système nerveux - (Responsable : François FERON)
- E3-BHE et neuroinflammation - (Responsable : Michel KHRESTCHATISKY)
- E4-Service Commun - (Responsable : Gérard CHARTON)
- Développement et Immunologie - Aix-Marseille II
- Neurosciences - Aix-Marseille I,II, III
| - | Targeting inflammation and neurogenesis using cannabinoids to delay the onset of Alzheimer’s disease. 2010 CDD de 4 ans pour un chercheur (Yannick Marchalant) - KHRESTCHATISKY M. - 2010-2013 - Marie Curie International Reintegration Grants (IRG) |
| - | Marie Curie International Reintegration Grants (IRG). (100.000 €). Targeting inflammation and neurogenesis using cannabinoids to delay the onset of Alzheimer’s disease. 2010 CDD de 4 ans pour un chercheur (Yannick Marchalant) dans le cadre de l’IRG auprès du CNRS et de l’Université Aix Marseille II. - KHRESTCHATISKY M. - 2010-2013 - Contrat Européen |
| - | Marie Curie International Reintegration Grants (IRG). (50.000 €). Role of RAGE in Alzheimer’s disease. 2009 CDD de 2 ans pour un chercheur (Lorena Perrone) dans le cadre de l’IRG auprès du CNRS. - KHRESTCHATISKY M. - 2009-2011 - Contrat Européen |
| - | Study of the effects of TWEAK on the blood brain barrier: towards a new therapeutic lead in multiple sclerosis ? - KHRESTCHATISKY M. - Coordinateur Sophie Desplat-Jego. - 2010-2013 - ANR TWEAKing |
| - | Projet labelisé par le Pôle de Compétitivité Eurobiomed. Peptide-vector-based drug targeting to the central nervous system - KHRESTCHATISKY M. - Coordinateur Patrick Vlieghe. - - ANR VECtoBRAIN |
| - | Functional interplay between the TIMP/MMP and the LRP-1 system in Alzheimer’s disease: new therapeutic targets”. Coordinateur. Projet labelisé par le Pôle de Compétitivité Eurobiomed. - Coordinateur Santiago Rivera - 2009-2012 - ANR |
| PHRC | |
| - | Etude des composantes de l'état redox chez le patient hémodialysé. - KHRESTCHATISKY M. - Co-IP: R. Guieu, E. Fenouillet, B. Dussol, P. Brunet. - 2009 - AP-HM |
| BAKLOUL Karima - TCH Vect-Horus | 04-91-69-87-29 |
| BARANGER Kevin - CR contractuel U2 | 04-91-69-87-70 |
| BARBOUCHE Rym - PU | 04-91-69-88-47 |
| BELZEAUX Raoul - Doctorant | 04-91-69-87-70 |
| BERNARD Anne - IE CNRS | 04-91-69-87-76 |
| BOONE Nathalie - Doctorant | 04-91-69-87-71 |
| CHABAS Jean-François - Doctorant | 04-91-69-89-64 |
| CHARRAT Eliane - TCH Universitaire | 04-91-69-87-71 |
| CHARTON Gérard - IE CNRS | 04-91-69-87-23 |
| CLEMENT Benoît - Doctorant | 04-91-69-87-70 |
| DAVID Marion - IE Vect-Horus | 04-91-69-87-76 |
| DE REGGI Max - DRCE CNRS | 04-91-69-89-65 |
| DESPLAT/JEGO Sophie - MCU-PH | 04-91-69-87-23 |
| FENOUILLET Emmanuel - DR CNRS | 04-91-69-88-47 |
| FERHAT Lofti - CR INSERM | 04-91-69-85-33 |
| FERON François - PU | 04-91-69-87-70 |
| FORTOUL Aude - TCH Vect Horus | 04-91-69-87-76 |
| GARCIA Madeleine - CR CNRS | 04-91-69-87-76 |
| GHARIB Bouchra - CR CNRS | 04-91-69-89-65 |
| GIRARD Stéphane - Doctorant | 04-91-69-87-29 |
| GRIMAUD Laurent - Doctorant | 04-91-69-85-33 |
| GUEYE Yatma - Doctorant | 04-91-69-85-23 |
| IBRAHIM El Cherif - CR CNRS | 04-91-69-87-71 |
| IVANOV Anton - IR CNRS | 04-91-69-89-64 |
| JABES Françoise - TCH Vect-Horus | 04-91-69-87-29 |
| JACQUOT Guillaume - CR Vect-Horus | 04-91-69-89-64 |
| KHRESTCHATISKY Michel - DR CNRS | 04-91-69-87-29 |
| MARCHALANT Yannick - CR CNRS | 04-91-69-89-45 |
| MBOUREHA Nassabia - ADT Vect-Horus | 04-91-69-89-64 |
| MOLINO Yves - IE Vect-Horus | 04-91-69-87-76 |
| MOUREAU Sophia - ADT CNRS | 04-91-69-89-65 |
| NGUYEN Angèle - AGT Universitaire | 04-91-69-89-64 |
| OULD-YAHOUI Adlane - Doctorant | 04-91-69-89-64 |
| PAREGNO Laurence - TCH CNRS | 04-91-69-89-64 |
| PERRONE Lorena - CR CNRS | 04-91-69-89-65 |
| REMY Jean-Jacques - CR INRA | 04-91-69-87-76 |
| RIVERA Santiago - DR CNRS | 04-91-69-87-71 |
| SBAI Oualid - CR CNRS | 04-91-69-85-23 |
| STEPHAN Delphine - AI ANR | 04-91-69-89-65 |
| VLIEGHE Patrick - CR Vect-Horus | 04-91-69-87-29 |
| Publications des 2 dernières années |
| - | Alluin, O., Wittmann, C., Marqueste, T., Chabas, J.F., Garcia, S., Lavaut, M.N., Guinard, D., Feron, F., and Decherchi, P. Functional recovery after peripheral nerve injury and implantation of a collagen guide. Biomaterials 2009, 30, 363-373. |
| - | Chabas JF, Dellavolpe C, Riah Y, Bron T, Reynier Y, Kaya JM, Casanova D. Cranial reconstruction after a post-craniotomy empyema. J Plast Reconstr Aesthet Surg. 2009, 62(6):e131-5 |
| - | Chabas, J.F., Alluin, O., Rao, G., Garcia, S., Lavaut, M.N., Legre, R., Magalon, G., Marqueste, T., Feron, F., and Decherchi, P. FK506 induces changes in muscle properties and promotes metabosensitive nerve fiber regeneration. J Neurotrauma 2009, 26, 97-108. |
| - | Clement, B., Trimaille, T., Alluin, O., Gigmes, D., Mabrouk, K., Feron, F., Decherchi, P., Marqueste, T., and Bertin, D. Convenient access to biocompatible block copolymers from SG1-based aliphatic polyester macro-alkoxyamines. Biomacromolecules 2009, 10, 1436-1445. |
| - | Desplat-Jego, S., Feuillet, L., Creidy, R., Malikova, I., Rance, R., Khrestchatisky, M., Hahm, K., Burkly, L.C., Pelletier, J., and Boucraut, J. TWEAK is expressed at the cell surface of monocytes during multiple sclerosis. J Leukoc Biol 2009, 85, 132-135. |
| - | Desplat-Jego, S., Feuillet, L., Creidy, R., Malikova, I., Rance, R., Khrestchatisky, M., Hahm, K., Burkly, L.C., Pelletier, J., and Boucraut, J. TWEAK is expressed at the cell surface of monocytes during multiple sclerosis. J Leukoc Biol 2009, 85, 132-135. |
| - | Eyles, D.W., Feron, F., Cui, X., Kesby, J.P., Harms, L.H., Ko, P., McGrath, J.J., and Burne, T.H. Developmental vitamin D deficiency causes abnormal brain development. Psychoneuroendocrinology 2009, 34 Suppl 1, S247-257. |
| - | Fernandes de Abreu, D.A., Eyles, D., and Feron, F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology 2009, 34 Suppl 1, S265-277. |
| - | Fernandes de Abreu, D.A., Babron, M.C., Rebeix, I., Fontenille, C., Yaouanq, J., Brassat, D., Fontaine, B., Clerget-Darpoux, F., Jehan, F., and Feron, F. Season of birth and not vitamin D receptor promoter polymorphisms is a risk factor for multiple sclerosis. Mult Scler 2009, 15, 1146-1152. |
| - | Feron, F., Delorme, B., Nivet, E., Gaillard, J., Haupl, T., Ringe, J., Deveze, A., Magnan, J., Sohier, J., Khrestchatisky, M., et al.. The human nose harbours a niche of olfactory ecto-mesenchymal stem cells displaying neurogenic and osteogenic properties. Stem Cells Dev 2009 11, 11. |
| - | Gepner, B., and Feron, F. Autism: a world changing too fast for a mis-wired brain? Neurosci Biobehav Rev 2009, 33, 1227-1242. |
| - | Ivanov, A., Esclapez, M., and Ferhat, L. Role of drebrin A in dendritic spine plasticity and synaptic function: Implications in neurological disorders. Commun Integr Biol 2009, 2, 268-270. |
| - | Ivanov, A., Esclapez, M., Pellegrino, C., Shirao, T., and Ferhat, L. Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons. J Cell Sci 2009, 122, 524-534. |
| - | Kalincik, T., Choi, E.A., Feron, F., Bianco, J., Sutharsan, R., Hayward, I., Mackay-Sim, A., Carrive, P., and Waite, P.M. Olfactory ensheathing cells reduce duration of autonomic dysreflexia in rats with high spinal cord injury. Auton Neurosci 2009, 5, 5. |
| - | Marchalant, Y., Brothers, H.M., Norman, G.J., Karelina, K., DeVries, A.C., and Wenk, G.L. Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis. Neurobiol Dis 2009, 34, 300-307. |
| - | Marchalant, Y., Brothers, H.M., and Wenk, G.L. Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain. Mol Psychiatry 2009, 14, 1067-1071. |
| - | Marcon, G., Tell, G., Perrone, L., Garbelli, R., Quadrifoglio, F., Tagliavini, F., and Giaccone, G. APE1/Ref-1 in Alzheimer's disease: An immunohistochemical study. Neurosci Lett 2009, 466, 124-127 |
| - | Ould-yahoui, A., Tremblay, E., Sbai, O., Ferhat, L., Bernard, A., Charrat, E., Gueye, Y., Lim, N.H., Brew, K., Risso, J.J., Khrestchatisky, and M Rivera, S. A new role for TIMP-1 in modulating neurite outgrowth and morphology of cortical neurons. PLoS One 2009,4, e8289. |
| - | Passamaneck, YJ, Katikala, L., Perrone, L., Dunn, MP, Oda-Ishii, I., and Di Gregorio, A. Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis. . Development 2009, 136, 3679-3689. |
| - | Perrone, L., Devi, TS, Hosoya, KI, Terasaki, T., and Singh, LP. Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. J Cell Physiol 2009, 221, 262-272. |
| - | Sambroni, E., Abdennebi-Najar, L., Remy, J.J., and Le Gac, F. Delayed sexual maturation through gonadotropin receptor vaccination in the rainbow trout Oncorhynchus mykiss. Gen Comp Endocrinol 2009, 164, 107-116. |
| - | Wojcik, L., Sawicka, A., Rivera, S., and Zalewska, T. Neurogenesis in gerbil hippocampus following brain ischemia: focus on the involvement of metalloproteinases. Acta Neurobiol Exp 2009, 69, 52-61. |
| - | Zani, M.L., Baranger, K., Guyot, N., Dallet-Choisy, S., and Moreau, T. Protease inhibitors derived from elafin and SLPI and engineered to have enhanced specificity towards neutrophil serine proteases. Protein Sci 2009, 18, 579-594. |
| - | Barbouche, R., Papandréou, M.J., Guieu, R., Rivera, S., Fantini, J., Khrestchatisky, M., Jones, I.M., and Fenouillet, E. Mapping of domains on HIV envelope protein mediating association with calnexin and protein disulfide isomerise. J. Biol. Chem. 2010, 285, 18 : 13788-13796 |
| - | Calarco, A., Petillo, O., Bosetti, M., Torpedine, A., Cannas, M., Perrone, L., Galderisi, U., Melone, MA, and Peluso, G. Controlled delivery of heparan sulfate/FGF-2 complex from polyelectrolyte scaffold promote maximal hMSC proliferation and differentiation. J Cell Biochem 2010, 110, 4 : 903-909 |
| - | Cornille, E., Abou-Hamdan, M., Khrestchatisky, M., Nieoullon, A., Reggi, M. d., and Gharib, B. Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury. BMC Neurosci. 2010, 11, 51 |
| - | Desplat-Jégo, S., Deharveng, I., Valéro, R., Bégu-Le Corroller, A., Vialettes, B. Antibodies cyclic citrullinated peptide antibodies (anti-CCP) in Type 1 diabetes. Diabetic Medicine. 2010, 27, 6 : 725-727 |
| - | Fernandes de Abreu, D.A., Nivet, E., Baril, N., Khrestchatisky, M., Roman, F., and Feron, F. Developmental vitamin D deficiency alters learning in C57Bl/6J mice. Behav Brain Res 2010, 15. |
| - | Fernandes de Abreu DA, Ibrahim EC, Boucraut J, Khrestchatisky M, Féron F Severity of experimental autoimmune encephalomyelitis is unexpectedly reduced in mice born to vitamin D-deficient mothers. J Steroid Biochem Mol Biol 2010, 121, 1-2 : 250-253 |
| - | Fernandes de Abreu, D.A., Nivet, E., Baril, N., Khrestchatisky, M., Roman, F., and Feron, F. Developmental vitamin D deficiency alters learning in C57Bl/6J mice. Behav Brain Res, 2010, 15. |
| - | Fernandes de Abreu, D.A., Nivet, E., Baril, N., Khrestchatisky, M., Roman, F., and Feron, F. Developmental vitamin D deficiency alters learning in C57Bl/6J mice. Behav Brain Res 2010, 15. |
| - | Henry JM, Boyer L, Belzeaux R, Baumstarck-Barrau K, Samuelian JC. Mental disorders among homeless people admitted to a French Psychiatric Emergency Service. Psychiatric Services, 2010, 61(3): 264-271 |
| - | Loubignac F, Chabas JF. A newly designed locked intramedullary nail for trochanteric hip fractures fixation: results of the first 100 Trochanteric implantation. Rev Chir Orthop Traumatol. 2010, 95(2):139-44 |
| - | Perrone, L., Mothers, E., Vignes, M., Mockel, A., Figueros, C., Maddelein, ML, and Faller, P. Copper Transfer from Cu-Abeta to Human Serum Albumin Inhibits Aggregation, Radical Production and Reduce Abeta Toxicity ChemBioChem 2010, 4, 110-118. |
| - | Samuelian, JC, Lancon C. Psychometric properties of the Activities Daily Life Scale (ADL). L’encéphale 2010, 36, 5 : 408-416 |
| - | Sbai, O., Ould-Yahoui, A., Ferhat, L., Gueye, Y., Bernard, A., Charrat, E., Mehanna, A., Risso, J.J., Chauvin, J.P., Fenouillet, E., Rivera, S., and Khrestchatisky, M. Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes. Glia 2010, 58, 344-366. |
| - | Sbai, O., Ould-Yahoui, A., Ferhat, L., Gueye, Y., Bernard, A., Charrat, E., Mehanna, A., Risso, J.J., Chauvin, J.P., Fenouillet, E., Rivera, S., and Khrestchatisky, M. Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes. Glia 2010, 58, 344-366. |
| - | Solberg, R., Andresen, J.H., Pettersen, S., Wright, M.S., Munkeby, B.H., Charrat, E., Khrestchatisky, M., Rivera, S., and Saugstad, O.D. Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes. Pediatr Res 2010, 67, 250-256. |
| - | Solberg, R., Andresen, J.H., Pettersen, S., Wright, M.S., Munkeby, B.H., Charrat, E., Khrestchatisky, M., Rivera, S., and Saugstad, O.D. Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes. Pediatr Res 2010, 67, 250-256. |
| - | Vlieghe, P., Lisowski, V., Martinez, J., and Khrestchatisky, M. Synthetic therapeutic peptides: science and market. Drug Discov Today 2010, 15, 40-56. |
| - | Vlieghe, P., Lisowski, V., Martinez, J., and Khrestchatisky, M. Synthetic therapeutic peptides: science and market. Drug Discov Today 2010, 15, 40-56. |
| Thèses des 2 dernières années |
| - | FERNANDES DE ABREU Diana - Vitamine D et sclérose en plaques : étude de trois polymorphismes du VDR humain et effets à long terme d'une carence développementale chez la souris - Université de la Méditerranée - 19/06/2009 |
| - | CEDILE Oriane - Expression physiologique et pathologique dans le SNC adulte de RAE-1, ligand du récepteur activateur NKG2D exprimé par les cellules NK potentiellement régulatrics dans l'EAE - Université de la Méditerranée - 28/09/2009 |
| - | BEL Christophe - Adressage polarisé de Caspr et Caspr2, Moléculaes d'adhérence axo-gliales - Université de la Méditerranée - 02/12/2009 |
| - | CORNILLE Emilie - L'hypométabolisme énergétique, une cible pour le traitement des maladies neurodégénératives - Université de la Méditerranée - 18/12/2009 |
| - | SBAI Oualid - Distribution, trafic et sécrétion vésiculaire des MMPs et leurs inhibiteurs dans les cellules - Université de la Méditerranée - 18/12/2009 |
© Faculté de Médecine de Marseill l Mentions légales l Mise à jour du 23 février 2012