|
TRANSPORTEURS MEMBRANAIRES , CHIMIORESISTANCE ET DRUG-DESIGNUFR Médecine - UMR MD1 / 27, boulevard Jean Moulin / 13385 Marseille 05
Téléphone : 04-91-32-45-87
Fax : 04-91-32-46-06
Courriel : Jean-Marie.Pages@univmed.fr
Equipes Acueil des Masters Contrats Liste des Personnels Publications des 2 dernières années Thèses
| Effectifs |
Enseignants - Chercheurs et Ingénieurs Universitaires : 6
Médecins hospitaliers :
Chercheurs et Ingénieurs (INSERM, CNRS, autres) : 8
Personnel Administratif et Technique Universitaire : 3
Personnel Administratif et Technique (INSERM, CNRS, autres) : 3
Internes :
Etudiants (3ème cycle,Post-Doc, Boursiers...) : 9
| Equipes de recherche |
- E1-Perméabilité et transporteurs membranaires, mécanismes de résistance associés - (Responsable : Jean-Marie PAGES)
- E2-Nouvelles cibles et molécules antimicrobiennes, synthèse et caractérisation - (Responsable : Jean-Marie PAGES)
- Service Commun - (Responsable : Jean-Marie PAGES)
- Chimie organique, Chimie du vivant - Aix-Marseille II et III
- Microbiologie, Biologie Végétale et Biotechnologie (MBVB) - Aix-Marseille I, II et III
| - | Emergence-Bio - Optimisation de l'activité et du potentiel de biodisponibilité du géraniol pour lutter contres les bactéries multi-résistantes aux drogues. - PAGES J.M./BOLLA J.M. - 2008-2011 - ANR |
| - | MIME - Les inhibiteurs de peptides déformylases - PAGES J.M./MEINNEL T. - 2008-2011 - ANR |
| ALIBERT Sandrine - MCF | 04-91-83-55-38 |
| BIOT Fabrice - IRBA MD, Doctorant | 04-76-63-68-40 |
| BOLLA Jean-Michel - CR INSERM | 04-91-32-44-40 |
| BORGES Jean-Philippe - Post-Doctorant | 04-91-32-45-87 |
| CHEVALIER Jacqueline - MCF | 04-91-78-29-88 |
| DAVIN-REGLI Anne - MCU-PH | 04-91-32-45-29 |
| FADLI Mariam - Doctorant | 04-91-32-45-87 |
| FAVARD Anne - ADT Universitaire | 04-91-32-45-87 |
| GARNOTEL Eric - SSA MD HIA | 04-91-61-71-13 |
| GOEMAERE Emilie - TCH ANR | 04-91-32-45-87 |
| GRABOWSKA Ania - Stage doctoral | 04-91-32-45-87 |
| JAMES Chloé - Post-Doctorant | 04-91-32-45-87 |
| KUETE Victor - Post-Doctorant | 04-91-32-45-87 |
| LAVIGNE Jean-Philippe - MCU-PH - Nîmes | 04-91-32-45-87 |
| LIEUTAUD Aurélie - TCH Universitaire | 04-91-32-45-87 |
| LORENZI Vannina - Post-Doctorant | 04-91-32-45-29 |
| MAHAMOUD Abdallah - MCF | 04-91-83-56-31 |
| MAMELLI Laurent - TCH ANR | 04-91-32-44-40 |
| MORILLON Marc - PRAG SSA MD | 04-91-61-71-13 |
| NICOLAS Pierre - SSA MD | 04-91-15-01-15 |
| PAGES Jean-Marie - DR INSERM | 04-91-32-45-87 |
| PENK Enrico - CR Ministère Affaires Etrangères | 04-91-83-56-31 |
| PENK Enrico - Post-Doctorant | 04-91-83-56-31 |
| QUENIN Solange - ADT Universitaire | 04-91-32-45-87 |
| RAGOT Céline - DES | 04-91-32-45-87 |
| SAEZ Emilie - TCH Protisvalor | 04-91-32-45-87 |
| SIMION Anamaria Roxana - Stage Master ETR | 04-91-32-45-87 |
| VALADE Eric - IRBA MD | 04-76-63-68-40 |
| VIDAL Dominique - IRBA MD | 04-76-63-69-19 |
| Publications des 2 dernières années |
| - | Alibert-Franco S., Pradines B., Mahamoud A., Davin-Regli A., Pagès J.-M. Efflux mechanism, an attractive target to combat multidrug resistant Plasmodium falciparum and Pseudomonas aeruginosa. Curr. Med Chem., 2009, 16(3): 301-17. |
| - | Fraisier C., Stor R., Tenebray B., Sanson Y., Nicolas P. Use of a new single multiplex PCR-based assay for direct simultaneous prediction of 6 Neisseria meningitidis serogroups. J. Clin. Microbiol. ,2009, 47(8): 2662-6. |
| - | Haddad N., Burns C.M., Bolla J.M., Prévost H., Fédérighi M., Drider D., Cappelier J.M. Long-term survival of Campylobacter jejuni at low temperatures is dependent on polynucleotide phosphorylase activity. Appl. Environ. Microbiol., 2009, 75(23): 7310-8. |
| - | Hedberg S.T., Fredlund H., Nicolas P., Caugant D.A., Olcén P., Unemo M. Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. Antimicrob. Agents Chemother., 2009, 53(4): 1561-6. |
| - | James C.E, Mahendran K.R., Molitor A., Bolla J.M., Bessonov AN, Winterhalter M, Pagès J.-M. How beta-lactam antibiotics enter bacteria: a dialogue with the porins. PLoS One, 2009, 4(5): e5453. |
| - | Le Pihive E., Blaha D., Chenavas S., Thibault F., Vidal D., Valade E. Description of two new plasmids isolated from Francisella philomiragia strains and construction of shuttle vectors for the study of Francisella tularensis. Plasmid, 2009, 62(3): 147-57. |
| - | Lorenzi V., Muselli A., Bernardini A.F., Berti L., Pagès J.-M., Amaral L., Bolla J.M. Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species. Antimicrob. Agents Chemother., 2009, 53(5): 2209-11. |
| - | Mamelli L., Petit S, Chevalier J., Giglione C, Lieutaud A, Meinnel T, Artaud I, Pagès J.-M. New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitors. PLoS One, 2009, 4(7): e6443. |
| - | Martins A., Iversen C., Rodrigues L, Spenglera G, Ramosa J, Kern WV, Couto I, Viveiros M, Fanning S, Pagès J.-M., Amaral L. AcrAB mediated MDR phenotype is maintained after efflux pump genes and their regulators have restored wild type activities. Int. J. Antimicrob. Agents, 2009, 34: 602-4. |
| - | Martins A., Spengler G., Rodrigues L., Viveiros M., Ramos J., Martins M., Couto I., Fanning S., Pagès J.-M., Bolla J.M., Molnar J., Amaral L. pH Modulation of efflux pump activity of multi-drug resistant Escherichia coli: protection during its passage and eventual colonization of the colon. PLoS One, 2009, 17;4(8): e6656. |
| - | Massenet D., Inrombe J., Mevoula D.E., Nicolas P. Serogroup W135 meningococcal meningitis, Northern Cameroon, 2007-2008. Emerg. Infect Dis., 2009, 15(2): 340-2. |
| - | Oliver M., Grandadam M., Marimoutou C., Rogier C., Botelho-Nevers E., Tolou H., Moalic J.l., Kraemer P., Morillon M., Morand J.J., Jeandel P., Parola P., Simon F. Persisting mixed cryoglobulinemia in chikungunya infections. Plos Negl. Trop. Dis., 2009, 3: e374. |
| - | O'Regan E., Quinn T., Pagès J.-M., McCusker M., Piddock L., Fanning S. Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of Rama and other global regulators. Antimicrob. Agents Chemother., 2009, 53(3): 1080-7. |
| - | Pagès J.-M., Amaral L. Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gramnegative bacteria. Biochim. Biophys. Acta, 2009, 1794(5): 826-33. |
| - | Pagès J.-M., Lavigne J.P., Leflon-Guibout V., Marcon E., Bert F., Noussair L., Nicolas-Chanoine M.H. Efflux pump, the masked side of beta-lactam resistance in Klebsiella pneumoniae clinical isolates. PLoS One, 2009, 4(3): e4817. |
| - | Randrianirina F., Vedy S., Rakotovao D., Ramarokoto C.E., Ratsitohaina H., Carod J.F., Ratsima E., Morillon M., Talarmin A Role of contaminated aspiration tubes in nosocomial outbreak of Klebsiella pneumoniae producing SHV-2 and CTX-M-15 extended-spectrum beta-lactamases. J. Hosp. Infect., 2009, 72(1): 23-9. |
| - | Thullier P., Pelat T., Vidal D. [Recombinant antibodies against bioweapons] Med. Sci. (Paris), 2009, 25(12): 1145-8. 75. Tran Q.T., Dupont M., Lavigne J.P., Chevalier J., Pagès J.-M., Sotto A., Davin-Regli A. Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. Antimicrob. Agents Chemother., 2009, 53(4): 1652-6. |
| - | Bialek S., Lavigne J.P., Chevalier J., Marcon E., Leflon-Guibout V., Davin-Regli A., Moreau R., Pagès J.-M., Nicolas- Chanoine M.H. Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in the Caenorhabditis elegans model. Antimicrob. Agents Chemother., 2010, 54, 10 : 4373-4378 |
| - | Chevalier J., Mahamoud A., Baitiche M., Adam E., Viveiros M., Smarandache A., Militaru A., Pascu M.L., Amaral L., Pagès J.-M. Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains. Int. J. Antimicrob. Agents, 2010, 36: 164-168. |
| - | Godreuil S., Renaud F., Choisy M., Depina J., Garnotel E., Morillon M., Van de Perre P., Bañuls A.L. Highly structured genetic diversity of Mycobacterium tuberculosis population in Djibouti. Clin. Microbiol. Infect,. 2010, 16, 7 : 1024-1026 |
| - | Hajjar E., Bessonov A., Molitor A., Kumar K., Mahendran K.R., Winterhalter M., Pagès J.-M., Ruggerone P., Ceccarelli M. Towards screening for antibiotics with enhanced permeation properties through bacterial porins: proof of concept. 2010, Biochemistry, 2010 49, 32 : 6928-6935 |
| - | Kuete V., Ngameni B., Tangmouo J.G., Bolla J.M., Alibert-Franco S., Ngadjui B.T., Pagès J.-M. Efflux pumps are involved in the Gram negative bacterial defense against isobavachalcone and diospyrone, two natural products. Antimicrob. Agents Chemother., 2010, 54: 1749-52. |
| - | Lavigne J.P., Brunel J.M., Chevalier J., Pagès J.-M. Squalamine, an original chemosensitizer to combat antibiotic resistant Gram-negative bacteria. J. Antimicrob. Chemother., 2010, 65: 799-801. |
| - | Martins A., Spengler G., Martins M., Rodrigues L., Viveiros M., Davin-Regli A., Chevalier J., Couto I., Pagès J.-M., Amaral L. Physiological characterization of the efflux pump system of antibiotic susceptible and multi-drug resistant Enterobacter aerogenes. Int. J. Antimicrob. Agents, 2010, 36, 4 : 313-318 |
| - | O'Regan E., Quinn T., Frye J.G., Pagés J.-M., Porwollik S., Fedorka-Cray P.J., Mcclelland M., Fanning S. Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enterica serotype enteritidis: reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes. Antimicrob. Agents Chemother., 2010, 54: 367-74. |
| - | Pagès J.-M., Alibert-Franco S., Mahamoud A., Bolla J.M., Davin-Regli A., Chevalier J., Garnotel E. Efflux pumps of Gramnegative bacteria, a new target for new molecules. Curr. Top. Med. Chem., 2010, 10, 18 : 1848-1857 |
| Thèses des 2 dernières années |
| - | TRAN Que-Tien - Resistance by modification of the membrane permeability in Proteus and Providencia. Characterization of the outer membrane components. Résistance par modification de la perméabilité membranaire chez Proteus et Providencia. Caractérisation des composantes de la membrane externe - Université de la Méditerranée - 16/12/2009 |
| - | MOLITOR Alexander - Régulation de la perméabilité membranaire chez les bactéries à gram négatif et la relatiobn avec la sensibilité aux antibiotiques - Université de la Méditerranée - 19/03/2010 |
© Faculté de Médecine de Marseill l Mentions légales l Mise à jour du 23 février 2012